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临床试验/NCT05330533
NCT05330533Unknown不适用

Effect of Recent Ejaculation on Scrotal Duplex Parameters in Infertile Males With Varicocele

Assiut University0 个研究点目标入组 200 人开始时间: 2022年11月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
200
主要终点
Assessment of varicose vein diameter pre and post ejaculation.

研究概览

简要总结

Evaluate the effect of recent ejaculation on scrotal duplex parameters in infertile males with varicocele

详细描述

Varicocele is abnormal dilatation of the pampiniform plexus veins draining the testicles.

It manifests as an abnormal retrograde flow in the internal spermatic venous system or dilation of venous branches in the external cremasteric system .

It affects approximately 15% in the general population, 35 - 40% in men with primary infertility and approximately 80% of men with secondary infertility. It could often concomitantly occur with infertility or chronic scrotal pain causing impaired spermatogenesis and is the most common correctable cause of male infertility. it may affects spermatogenesis via different mechanisms such as increased testicular heat, hormonal disorders and reflux of toxic metabolites.

Scrotal colour Doppler ultrasonography (USG) is a widely used method for evaluation of varicocele patients . It can be used along with physical examination in these patients through evaluation of vein reflux and diameter; in cases where palpation may be problematic. Furthermore, the degree of reflux and vein diameter can be used during the decision-making stage while treating varicocele .

Ejaculation is the process by which sperms move from epididymis via vas deferens to urethra and finally expelled out through the urethral meatus by the contraction of smooth muscles. A normal antegrade ejaculation consists of emission, expulsion (ejection), and orgasm .

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • Infertile male patients.
  • patients with scrotal varicocele.
  • male patients aging over 18 years old.

排除标准

  • Pyospermia.
  • Epididymitis.
  • Anejaculation.
  • Recurrent varicocele.
  • Patients who previously underwent scrotal or inguinal surgery.

结局指标

主要结局

Assessment of varicose vein diameter pre and post ejaculation.

时间窗: within 30 minutes post ejaculation

Assessment of the change in varicose vein diameter by scrotal colour doppler ultrasonography pre ejaculation and within 30 minutes post ejaculation.

次要结局

  • Assessment of varicose vein reflux time pre and post ejaculation.(Within 30 minutes post ejaculation)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mahmoud Thabet Mohamed Ali Elsebaity

Principal investigator , resident doctor

Assiut University

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