Pattern of Prescribing Anticoagulants As DVT Prophylaxis in Intensive Care Unit of Tertiary Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Padua score for medical patients
研究概览
简要总结
Hospitalized patients are at high risk of venous thromboembolism (VTE), and the appropriate use of thromboprophylaxis can significantly reduce the incidence of VTE in high-risk patients. We investigated the pattern of VTE prophylaxis administration among elderly medical patients and assessed its appropriateness based on the American College of Chest Physicians (ACCP) recommendations. Methods A cross-sectional single-center study will be conducted between July 2024 and December 2024, including hospitalized (> 48 h), (≥ 60 years), medical and surgical patients, and excluding patients receiving anticoagulant for other reason, having contraindication to thromboprophylaxis, or had VTE diagnosed within 48 h. The Padua and caprine prediction scores will be used to determine the patients' risk for VTE, and thromboprophylaxis use will be assessed against the ACCP recommendations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient records
- •admitted to the ICU with
- •medical or surgical causes
- •recieved anticoagulants for DVT prophylaxis
排除标准
- •Patients already on anticoagulant therapy,
- •had history of previous DVT,
- •had End-stage liver disease,
- •admitted with hemorrhage/bleeding
- •not prescribed DVT prophylaxis
结局指标
主要结局
Padua score for medical patients
时间窗: within 24 hours of ICU admission
Venous thromboembolism Risk assessment (Scores 0-3 are low risk and do not warrant prophylaxis. Scores ≥4 are high risk for VTE and subsequent complications; recommendation for thromboprophylaxis.)
Caprini score for surgical patients
时间窗: within 24 hours of ICU admission
Venous thromboembolism Risk assessment (Total score of 0-1: Low risk of VTE Total score of ≥3: High/moderate risk of VTE )
次要结局
- Adverse drug reaction cost(within 24 hours of ICU admission till ICU discharge (at least 48 hours))
- Bleeding risk assessment(within 24 hours of ICU admission)
- Direct Anticoagulant cost(within 24 hours of ICU admission till ICU discharge(at least 48 hours))
研究者
Sarah Sabry Hashem
Clinical Pharmacy Associate Professor
Egyptian Chinese University