ACTRN12619001728123招募中1 期
Pharmacologically Targeting Sleep Spindles to Improve Cognition in Ageing
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 50 Years 至 75 Years（—）
- 性别
- All
入选标准
- •1. Males and Females;
- •2. Age 50-75;
- •3. Ability to perform neurobehavioural tests;
- •4. Able to give informed consent;
- •5. Fluent in English;
- •6. Cognitively intact (may have subjective memory complaint)
排除标准
- •1. Mild cognitive impairment, suspected or confirmed dementia or Mini Mental State Examination <24 ;
- •2. History of cerebrovascular events (e.g. stroke, TIA) associated with persisting cognitive changes
- •3. Neurological disorders (e.g. Parkinson’s Disease, Epilepsy, Multiple Sclerosis)
- •4. Myasthenia Gravis
- •5. Severe hepatic impairment
- •6. Acute ± severe pulmonary insufficiency
- •7. Head trauma with associated loss of consciousness > 30 mins
- •8. Psychiatric disorder including; Bipolar Disorder (I and II) and schizophrenia
- •9. Current major depressive episode
- •10. Currently regularly taking regular benzodiazepines, sedatives and hypnotics, and other sleep-affecting medications or any centrally active medications including anti-depressants /polypharmacy.
- •11. Current substance abuse or dependence (alcohol and/or other illicit substances)
- •12. Shift-work or trans-meridian travel within 14 days of assessment
- •13. Obstructive Sleep Apnoea and other sleep disorders;
- •14. Severe insomnia (insomnia severity index score of 22 or more)
- •15. Contraindication to MRI scanning.
- •16. Clinically significant medical condition that may hinder compliance with protocol as determined by the study physician.
- •17. Pregnancy
研究者
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