The Effect Site Concentration of Remifentanil Blunting Hemodynamic Responses to Tracheal Intubation: Single Versus Double Lumen Tube
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Changes from baseline in heart rate and mean arterial pressure after intubation
研究概览
简要总结
The purpose of this study is to evaluate the effect site concentration of remifentanil blunting hemodynamic changes to tracheal intubation of single or double lumen tubes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing thoracic surgery that require one lung ventilation
排除标准
- •patient who does not agree with this study
- •BMI < 16.0 or BMI > 30
- •cardiovascular disease, pulmonary disease, renal disease
- •alcoholic abuser or drug abuser
- •patient who takes any drug to influence cardiovascular system or sympathetic nervous system
- •any use of local anesthetics or drugs to influence cardiovascular system during tracheal intubation
研究组 & 干预措施
Single lumen tube
Single lumen tube intubation during remifentanil infusion
干预措施: Remifentanil (Drug)
Double lumen tube
Double lumen tube intubation during remifentanil infusion
干预措施: Remifentanil (Drug)
结局指标
主要结局
Changes from baseline in heart rate and mean arterial pressure after intubation
时间窗: intubation period
Heart rate and mean arterial pressure will be recorded at 2 minutes before intubation, 1 minute before intubation, during intubation, 1 minute after intubation. The mean value of heart rate and mean arterial pressure before intubation will be regarded as the baseline values. If maximum heart rate or mean arterial pressure after intubation increased by \>15% from baseline value, the response will be regarded as "fail" and increased concentration of remifentanil will be applied to next patient by up and down sequential method.
次要结局
未报告次要终点
研究者
Jae-Hyon Bahk, MD, PhD
professor
Seoul National University Hospital