The Use of FSH Receptor Polymorphisms To Improve Pregnancy Rates In In-Vitro Fertilization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- The primary outcome measure is to evaluate the frequency of FSH receptor polymorphisms in our population.
研究概览
简要总结
This study is being done to identify if certain sequences (patterns) of key genes (called polymorphisms) may predict a response to fertility medications. The investigators will also determine if the individual response to fertility medications affects pregnancy rates in in-vitro fertilization.
详细描述
All IVF patients who meet inclusion criteria and not exclusion criteria will be asked to participate in this study. Upon consent, a blood sample will be obtained in 2 EDTA containing lavender topped tubes before, during or within 3 months after their IVF cycle. Genomic DNA will be extracted and saved for genotyping.
The Investigators will collect data on each individual's age, ethnic background, and estradiol levels on the day of hCG administration, total gonadotropin amount, clinical pregnancy rates, basal FSH levels, and occurrence of OHSS. The Investigators will then analyze all samples from all patients for their FSH receptor genotypes.
Patients will be compensated $75 via a check within 6-8 weeks of their blood drawn.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •100 women less than 35 years old at time of signing the Informed Consent Form.
- •Day 3 FSH level less than or equal to 10 mIU/ml with an estradiol < 70 pg/ml
- •Day 3 antral follicle count of greater than 10 follicles total.
- •Couples who have male factor infertility, tubal factor infertility, and unexplained infertility.
- •Exclusion Criteria patients who have:
- •Endometriosis
- •Polycystic ovarian syndrome
排除标准
- 未提供
结局指标
主要结局
The primary outcome measure is to evaluate the frequency of FSH receptor polymorphisms in our population.
时间窗: 3 years
The investigators are looking to quantify how often certain FSH receptor Polymorphisms occur in the population and cetain racial groups. We will be looking at patient's race along with the laboratory results.
次要结局
- The secondary outcome is to further clarify the variation in response to FSH due to FSH receptor polymorphisms using the protocols largely used in the United States, including our center.(3 years)
研究者
Peter McGovern, MD
Director
University Reproductive Associates