NCT03922893招募中不适用
Discovery and Characterization of Susceptibility Genes in Adults and Children With Suspected Hereditary Cancer Predisposition
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 7
- 主要终点
- Discovery of novel cancer susceptibility genes
研究概览
简要总结
This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals who have undergone clinical and/or research genetic evaluation, found to have or not have a germline genetic variant (pathogenic, likely pathogenic, variant of uncertain/unknown significance, likely benign).
- •Individuals with or without a personal history of malignant or pre-malignant lesions who demonstrate: a) clinical findings suggestive of a genetic cancer susceptibility syndrome including very early age at onset, multiple primary malignancies, or other features; and/or b) family histories suggestive of a genetic cancer susceptibility syndrome, or c) other features suggesting inherited etiology of malignancy as determined by the PI.
- •Family members of the above participants. Both children (with parental consent as age appropriate) and adults are eligible to participation.
- •Individuals may or may not be enrolled MSK patients; probands may be referred to (or self-referred to) the study and may be enrolled at discretion of the PI and if able to provide informed consent.
- •Biospecimens derived from deceased family members may be used for research in this study if consent if provided by the executor of the estate of that individual.
排除标准
- •Patients will be excluded from this study if he/she has physical, cognitive or psychiatric conditions that interfere with ability to give meaningful informed consent.
结局指标
主要结局
Discovery of novel cancer susceptibility genes
时间窗: Up to 10 years
次要结局
未报告次要终点
研究者
研究点 (7)
Loading locations...
相似试验
尚未招募
不适用
Identification and Characterization of Genetic Variants in Hereditary AngioedemaHereditary Angioedema With C1 Esterase Inhibitor DeficiencyNCT05833620Hospital Universitari Vall d'Hebron Research Institute200
已完成
不适用
Primary Hyperoxaluria Mutation GenotypingPrimary HyperoxaluriaNCT00589225Mayo Clinic902
进行中（未招募）
2 期
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's DiseaseAlzheimer DiseaseNCT04840979Columbia University107
已完成
不适用
Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic CancerPancreatic Ductal AdenocarcinomaNCT02790944Ambry Genetics300
已完成
不适用
A Study to Investigate the Family History of Cancer in Patients With Non-small Cell Lung Cancer (FAHIC - Lung).Non Small Cell Lung CancerNCT06196424Fondazione Policlinico Universitario Campus Bio-Medico336