NL-OMON52406招募中不适用
Morphine or Fentanyl for Refractory dyspnea in COPD - MoreFoRCOPD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age >=40 years
- •Read, understood and signed the Informed Consent form
- •COPD GOLD class III or IV, according to GOLD criteria.
- •- Post-bronchodilatation FEV1/FVC < 70% and FEV1 < 50% pred.
- •Complaints of refractory dyspnea as established by patient and doctor.
- •mMRC score >= 3.
- •Life expectancy of >= 2 months.
- •Optimized standard therapy according to Dutch LAN guideline for diagnosis and
- •treatment of COPD.
排除标准
- •Other severe disease with chronic pain or chronic dyspnea (a non-susbstantial
- •component of left sided heart failure is acceptable).
- •Current use of opioids for whatever indication
- •Allergy / intolerance for opioids
- •Psychiatric disease, not related to severe COPD.
- •Exacerbation of COPD eight weeks prior to inclusion or between screening and
- •randomization.
- •Problematic (leading to medical help or social problems) substance abuse
- •during the last five years.
- •Active malignancy, with the exception of planocellular or basal cell
- •carcinoma of the skin.
- •eGFR 15 ml/min
研究者
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