Extinction Learning in Adults With Tourette Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Tic severity as assessed by the Hopkins Motor and Vocal Tic Scale (HM/VTS)
研究概览
简要总结
Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still understudied for individuals with Tourette syndrome (TS). This study examines extinction learning and extinction recall in adults with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years old,
- •Have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (>9 for youth with motor or vocal tics only)
- •Have not received more than 4 previous sessions of HRT
- •Be fluent in English
- •Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment.
排除标准
- •An inability to complete rating scales
- •An inability to attend study visits
结局指标
主要结局
Tic severity as assessed by the Hopkins Motor and Vocal Tic Scale (HM/VTS)
时间窗: Within 1 week after completion of HRT
Patient will nominate up to five motor and five vocal tics they deem bothersome on the HM/VTS. Each bothersome tic is then rated by a clinician on the composite two (vocal and motor) 5-point HM/VTS scale ranging from none (0) to severe (4) for the motor as well as vocal tics. The individual tic scores are summed (minimum of 0 and maximum of 40) and averaged together to create an average tic severity score.
次要结局
- Tic severity as assessed by the Yale Global Tic Severity Scale-Revised (YGTSS)(Within 1 week after completion of HRT)