Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Mean recovery time for T4/T1 ratio > 90% after sugammadex administration
研究概览
简要总结
Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting. Recent animal data have shown that dexamethasone may impair the reversal effect of sugammadex. The objective of this randomised controlled trial is to confirm in the clinical practice these preliminary results.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients scheduled to undergo microlaryngoscopy and ear-nose-throat endoscopic procedures
排除标准
- •contraindication to dexamethasone administration
- •contraindication to sugammadex administration
- •contraindication to rocuronium administration
研究组 & 干预措施
No IV dexamethasone
Patients will receive an equivalent volume of normal saline.
干预措施: Normal saline (Drug)
IV dexamethasone
Patients will receive 0.1 mg/kg of dexamethasone.
干预措施: IV dexamethasone (Drug)
结局指标
主要结局
Mean recovery time for T4/T1 ratio > 90% after sugammadex administration
时间窗: surgical procedure
次要结局
- Mean recovery time for T4/T1 ratio > 70% after sugammadex administration(surgical procedure)
- Mean recovery time for T4/T1 ratio > 80% after sugammadex administration(surgical procedure)
研究者
Eric Albrecht
Program Director, Regional Anaesthesia
Centre Hospitalier Universitaire Vaudois