Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- The incidence of cough
研究概览
简要总结
The investigators aimed to investigate the effects of pretreatment with different doses of dexmedetomidine on the cough caused by fentanyl during anesthetic induction.
Patients undergoing elective surgeries under general anesthesia will be randomly allocated to 4 groups (n = 60, each group). Dexmedetomidine 0, 0.03, 0.06, and 0.09 μg/kg/min will be pump-administered in 10 mins to groups I, II, III, and IV, respectively, followed by the induction of general anesthesia with intravenous fentanyl 4 μg/kg. The incidences and severity of cough that occurred within 2 min after the injection of fentanyl will be recorded, and the incidences of cardiovascular adverse events that occurred between the administration of the dexmedetomidine infusion and 2 min after tracheal intubation will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing elective surgeries under general anesthesia.
排除标准
- •Patients with contraindications of dexmedetomidine.
- •Patients younger than 18 years old and older than 65 years old.
研究组 & 干预措施
Dexmedetomidine 0 μg/kg/min
干预措施: Dexmedetomidine (Drug)
Dexmedetomidine 0.03 μg/kg/min
干预措施: Dexmedetomidine (Drug)
Dexmedetomidine 0.06 μg/kg/min
干预措施: Dexmedetomidine (Drug)
Dexmedetomidine 0.09 μg/kg/min
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
The incidence of cough
时间窗: After the infusion of dexmedetomidine up to 10 minutes
Yes or No
The time of cough
时间窗: After the infusion of dexmedetomidine up to 10 minutes
After the infusion of dexmedetomidine up to 10 minutes
The severity of cough
时间窗: After the infusion of dexmedetomidine up to 10 minutes
minor, moderate, severe
The occurence of adverse effects of dexmedetomidine
时间窗: After the infusion of dexmedetomidine up to 10 minutes
bradycardia, hypotension, hypertension
次要结局
未报告次要终点
研究者
Zhuan Zhang
Director
Yangzhou University