Effect of Glucose Versus Mixed Breakfast on Metabolic and Neurofunctional Responses in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Effect of glucose vs different kind of breakfasts on cognitive performances via brain evoked-potentials measure
研究概览
简要总结
This study aims at assessing the effects of glucose and different types of breakfast on metabolic and neurofunctional responses in healthy individuals.
Twelve healthy subjects, on a stable diet, in a randomized-crossover fashion, received either a 50 g glucose load (control) or one of these breakfast:
B1: milk (125ml) and cereals (30g); B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g); B3: milk (125ml), bread (50g), apple (150g) and hazelnut cream chocolate (15g). Prior and upon completion of each tolerance test, an EEG was performed to measure frontal P300-evoked potentials.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18.5 - 24.9 kg/m2
- •normal glucose tolerance
- •stable diet
排除标准
- •type 1 and type 2 diabetes
- •impaired glucose tolerance
- •dyslipidemia
- •metabolic syndrome
研究组 & 干预措施
Glucose
EEG_pre + Oral glucose tolerance test (50-g OGTT) + EEG_post
干预措施: EEG_pre (Device)
Glucose
EEG_pre + Oral glucose tolerance test (50-g OGTT) + EEG_post
干预措施: EEG_post (Device)
Milk + Cereals
EEG_pre + B1: milk (125ml) and cereals (30g) + EEG_post
干预措施: Milk & Cereals (Dietary Supplement)
Milk + Cereals
EEG_pre + B1: milk (125ml) and cereals (30g) + EEG_post
干预措施: Milk, apple & snack (Dietary Supplement)
Milk + Cereals
EEG_pre + B1: milk (125ml) and cereals (30g) + EEG_post
干预措施: EEG_pre (Device)
Milk + Cereals
EEG_pre + B1: milk (125ml) and cereals (30g) + EEG_post
干预措施: EEG_post (Device)
Milk + Apple + Snack
EEG_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG_post
干预措施: Milk & Cereals (Dietary Supplement)
Milk + Apple + Snack
EEG_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG_post
干预措施: Milk, apple & bread w/ cream (Dietary Supplement)
Milk + Apple + Snack
EEG_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG_post
干预措施: EEG_pre (Device)
Milk + Apple + Snack
EEG_pre + B2: milk (220ml), apple (200g) and cream chocolate filled sponge cake (30g) + EEG_post
干预措施: EEG_post (Device)
Milk + Apple + Bread w/ cream
EEG_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG_post
干预措施: Milk & Cereals (Dietary Supplement)
Milk + Apple + Bread w/ cream
EEG_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG_post
干预措施: Milk, apple & bread w/ cream (Dietary Supplement)
Milk + Apple + Bread w/ cream
EEG_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG_post
干预措施: EEG_pre (Device)
Milk + Apple + Bread w/ cream
EEG_pre + B3: milk (125ml), apple (150g), and bread (50g) with hazelnut chocolate cream (15g) + EEG_post
干预措施: EEG_post (Device)
Glucose
EEG_pre + Oral glucose tolerance test (50-g OGTT) + EEG_post
干预措施: Glucose (Dietary Supplement)
结局指标
主要结局
Effect of glucose vs different kind of breakfasts on cognitive performances via brain evoked-potentials measure
时间窗: The incremental (post-pre) frontal P300 potential was assessed as a "change" ( before and 180 min after consumption)
On the same morning of the glucose tolerance test, before and 180 min after consumption, an EEG was performed to record P300 wave-evoked potentials.
次要结局
- Effect of glucose vs different kind of breakfasts on AUC_glycemia in healthy subjects(Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion.)
- Effect of glucose vs different kind of breakfasts on AUC_ghrelinemia in healthy subjects.(Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion.)
- Effect of glucose vs different kind of breakfasts on AUC_insulinemia in healthy subjects.(Blood samples are drawn at -15, 0, 15, 30, 45, 60, 75, 90, 120 minutes with respect to the ingestion.)