Effects of dexmedetomidine on prevalence of succinylcholine induced fasciculations and post operative myalgia A randomized , controlled, double blinded study

This study is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of Dexmedetomidine on Succinylcholine-induced fasciculations and postoperative myalgia in adult patients undergoing elective surgeries under general anesthesia. Succinylcholine, though widely used for rapid sequence intubation due to its fast onset and short duration, is associated with side effects like muscle fasciculations and postoperative muscle pain, which can impact patient satisfaction and recovery. Dexmedetomidine, an alpha-2 adrenergic agonist with sedative, analgesic, and sympatholytic properties, is hypothesized to reduce these adverse effects due to its pharmacological profile. Participants are randomly allocated into two groups: one receiving intravenous Dexmedetomidine before Succinylcholine administration and the other receiving a placebo. Parameters including the incidence and severity of fasciculations, as well as the intensity and duration of postoperative myalgia, will be assessed and compared between the two groups. The primary objective is to determine whether Dexmedetomidine pre-treatment can provide a clinically significant reduction in Succinylcholine-induced complications, thereby enhancing the safety and comfort of patients undergoing surgery.