Assessment of Lung Structure and Function of Infants Born Prematurely
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Pulmonary Function Testing
研究概览
简要总结
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
详细描述
SPECIFIC AIM #1:
Determine the relationship between parenchymal tissue and alveolar volume with normal lung growth early in life.
We hypothesize that during the first two years of life that parenchymal surface area and alveolar volume increase with somatic growth; however, the ratio of surface area to volume remains constant, while ventilation within the lung becomes more homogenous.
SPECIFIC AIM #2:
Determine the pulmonary sequelae of premature birth and assess the effectiveness of early treatment strategies upon the pulmonary sequelae.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 2 Months 至 36 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •37 weeks or greater gestational age
- •Age 2 to 36 months
- •37 weeks or greater gestational age having a CT scan for non-respiratory issues.
- •Age 2-36 months
- •23-35 weeks gestational age
排除标准
- •Group 1 and Group 2:
- •Congenital cardio-respiratory disease
- •Hospitalization for respiratory illness
- •Treatment with asthma medications
- •Small for gestational age at birth
- •Congenital cardio-respiratory disease
- •Severe developmental delay
结局指标
主要结局
Pulmonary Function Testing
时间窗: day of testing
Forced expiratory Flows, Single-breath diffusion capacity and alveolar volume
次要结局
未报告次要终点
研究者
Robert Tepper
Robert Tepper
Indiana University