Role of Hepatic Glycogen on Nocturnal EGP in T2D
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Hepatic Glycogen Content and Rates of Gluconeogenesis in Subjects With Type 2 Diabetes
研究概览
简要总结
The experimental approach in this study intends to investigate the role of hepatic glycogen content on nocturnal regulation of endogenous glucose production including the relative contributions of glycogenolysis and gluconeogenesis and the extent to which this differs between subjects with type 2 diabetes and subjects without diabetes. Both participants with type 2 diabetes and participants without diabetes will be studied after consuming either a low carbohydrate (no glycogen loading) or high carbohydrate (glycogen loading) diet.
详细描述
Physiology study for looking at glycogen loading vs non loading in improving nightime glucose tolerance by increasing glycogen in liver and resulting higher glycogenolysis at night.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
A total of 34 subjects participated.
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 30-75
- •BMI 20-35kg/m^2
- •Participants with type 2 diabetes:
- •HbA1c less than or equal to 8.5% on lifestyle therapy or monotherapy with metformin or sulphonylureas (SU); or less than or equal to 7.5% on two oral hypoglycemic agents (Metformin and SU)
排除标准
- •Pregnancy or breast feeding
- •Morbidities precluding participation
- •Participants with type 2 diabetes:
- •Therapy with insulin
- •SGLT2 inhibitors
- •GLP-1 based approaches
- •Unstable diabetic retinopathy
- •Microalbuminuria
- •Macrovascular disease
- •Medications affecting GI motility (eg., erythromycin, pramlintide)
- •Upper GI disorder/surgery
- •Participants without diabetes:
- •Medications (except stable thyroid hormone or hormone replacement therapy) that could influence glucose tolerance
- •History of diabetes mellitus in first degree family members or prior history of diabetes mellitus or gestational diabetes, or pre-diabetes
结局指标
主要结局
Hepatic Glycogen Content and Rates of Gluconeogenesis in Subjects With Type 2 Diabetes
时间窗: Subjects will complete both glycogen loading and no glycogen loading visits within approximately 6 weeks
We measured the rates and contribution of Gluconeogenesis (GNG) to nocturnal Endogenous Glucose Production (EGP) using the deuterated water technique after either glycogen loading or no glycogen loading in subjects with type 2 diabetes.
次要结局
- Rates of Glycogenolysis in Subjects With Type 2 Diabetes(Subjects will complete both glycogen loading and no glycogen loading visits within approximately 6 weeks)
- Rates of Gluconeogenesis in Healthy Subjects(Subjects will complete both glycogen loading and no glycogen loading visits within approximately 6 weeks)
研究者
Rita Basu
Principal Investigator
University of Alabama at Birmingham