Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS
研究概览
简要总结
The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms.
Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.
详细描述
Women with regularly menstrual cycle will enroll in the study than will separate two groups:
Study group: women with vaginal candidiasis ( diagnosed by clinic and lab.)
Control group: women ( not have any vaginal infections candida and others)
Saliva samples will be taken from two groups than HST-5 level will be analyzed. Finally HST-5 levels of the two groups will be compared .
Women with diabetes, immun deficiency, pregnancy, virgin, menopausal period , premature ovarian failure will be excluded.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women with regularly menstrual cycle , diagnosed candidal vaginosis and not have any vaginal infection.
排除标准
- •diabetes, immun deficiency, menopause, premature ovarian failure, pregnancy, virgin
结局指标
主要结局
SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS
时间窗: 1 month
we done salivary protein electrophoresis( as a small sample group ; consist of vaginal candidiasis and control patients) and Hst5 protein band was seen
次要结局
- SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS(2 month)
研究者
Irem Senyuva
M.D, Obstetrics and Gynecology
Usak State Hospital