Determination of the Tolerable Upper Intake Level (UL) of Leucine in Healthy Elderly Men (70-75 Yrs)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- 13 carbon dioxide production
研究概览
简要总结
Amino acid are the building blocks of the body's protein. Some amino acids, including leucine, cannot be made in the body and must be obtained from diet, these are called essential. With increase in age the body's muscle mass decrease and studies have suggested that dietary supplementation of leucine may have potential health benefits in elderly in regards to prevention of age related loss of lean muscle mass, and thus may help improve the quality of life in elderly.
Currently, a safe upper dietary intake level of leucine has not been established for healthy elderly. Prior to exploring whether leucine supplementation will prevent or decrease loss of lean muscle mass in elderly we propose to identify the upper intake of leucine in healthy elderly.
The purpose of this study is to determine the tolerable upper intake level (UL) of leucine in healthy elderly men (70 - 75 yrs)
The investigators hypothesize that with a careful graded stepwise increase in leucine intake in elderly men, above the Estimated Average Requirement (EAR - 50 mg/kg/d), the body's ability to oxidize/dispose of excess amino acids will reach a maximum. With increased leucine intakes we hypothesize an increase in plasma ammonia concentrations and increases in plasma leucine and urinary leucine excretion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 75 Years（Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men 70 - 75 years of age
- •Free of chronic diseases including; sarcopenia, heart disease, kidney disorders, liver disease, chronic high blood pressure and or diabetes.
- •Free of any cognitive disorders
- •Men not enrolled in any other research studies
- •Men who are not claustrophobic
排除标准
- •Men not within the age 70 -75 years
- •Men diagnosed with a chronic diseases including; sarcopenia, heart disease, kidney disorders, liver disease, chronic high blood pressure and/or diabetes
- •Men allergic to milk, eggs and egg protein
- •Men who are claustrophobic
- •Men who are currently enrolled in other research studies
研究组 & 干预措施
Leucine intake
Dietary supplement: Leucine intake
干预措施: Leucine intake (Dietary Supplement)
结局指标
主要结局
13 carbon dioxide production
时间窗: 8 hours (1 study day)
Urine, plasma and breath samples will be collected during the study to measure the rate of oxidation of the tracer.
次要结局
未报告次要终点
研究者
Rajavel Elango, PhD
Principle Investigator
University of British Columbia