Determination of Lysine Requirements in Healthy Pregnant Women Using the Indicator Amino Acid Oxidation Technique
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- 13 carbon dioxide production
研究概览
简要总结
Amino acids are building blocks of protein in our body. It is important that pregnant women eat adequate amount of protein/amino acids to ensure healthy growth and development of the fetus.Lysine is an amino acid that is present in high amounts only in animal foods (meat) and not much in plant foods such as wheat. Currently , it is not known how much lysine is needed to eat during pregnancy.
Current Dietary Reference Intake recommendations for amino acid requirements are based on non-pregnant adults, and minimally based on pregnancy-specific data.To the investigators knowledge, there is no scientific information regarding the amount of lysine needed at different stages of pregnancy.
The investigators hypothesize that current recommendations for lysine intake in pregnant women are underestimated. The investigators also hypothesize that the lysine requirements will be greater during the later stages of pregnancy, compared to early stages.
The purpose of this study is to determine lysine requirements in healthy pregnant women 19-40y,(1st and 3rd trimester) using a modern, safe and quick technique called the indicator amino acid oxidation technique and to compare lysine requirements during early (15-18 weeks last menstrual period) late (33-36 weeks last menstrual period) stages of pregnancy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Singleton pregnancy
- •Maternal age 19-40y
- •Early stage of pregnancy(15-18 weeks) and late stage of pregnancy(33-36 weeks)
- •In good health (free of chronic/acute illness, full range of physical mobility)
- •Healthy pre-pregnancy body mass index
排除标准
- •Subjects outside the age range of 19-40y
- •Women pregnant with more than one child
- •Body mass Index less than 18.5kg/m2 or greater than 25 kg/m2
- •less than 18 months between current pregnancy and last pregnancy
- •History of spontaneous abortion,pre-term birth, preeclampsia/eclampsia, gestational diabetes, pregnancy-related anemia, pregnancy related jaundice
- •Existing metabolic disease
- •Substance dependance (i.e. alcohol, cigarette, illicit drugs)
- •Allergic to eggs and egg protein
- •Severe nausea and vomiting during pregnancy
结局指标
主要结局
13 carbon dioxide production
时间窗: 8 hours (1 study day)
Urine and breath samples will be collected during the study to measure the rate of oxidation of tracer in expired breath and flux by enrichment in urine.
次要结局
未报告次要终点
研究者
Rajavel Elango, PhD
Principle Investigator
University of British Columbia