Determination Glycine Requirements During Healthy Pregnancy Using the Indicator Amino Acid Oxidation (IAAO) Technique
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- 13 Carbon dioxide production
研究概览
简要总结
It is important that pregnant women eat an adequate amount of protein to ensure healthy growth and development of the fetus. Amino acids are the building blocks of the body's protein. Glycine is an amino acid that can be made in the body, but under certain metabolic circumstances (e.g. pregnancy) the body's needs may be higher and thus glycine must be obtained from the diet. Currently, it is not known how much glycine may be needed from the diet during pregnancy. We plan to study dietary glycine requirements in healthy pregnant women, during early and late gestation. We will do this using a modern, safe and quick method.
详细描述
Purpose:
To determine the dietary glycine requirement in healthy pregnant women during mid (20 - 30 weeks) and late (31 - 40 weeks) gestation.
Hypothesis:
We hypothesize that there is a dietary requirement for glycine during pregnancy due to an increased metabolic demand. With increased glycine intake we hypothesize to observe an increase in protein synthesis, as measured by the indicator amino acid oxidation (IAAO) method.
Justification:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Healthy pregnant women aged 20 - 40 yrs
- •Singleton pregnancy
- •Mid (20 - 30 weeks of gestation) or late stages of pregnancy (31 - 40 weeks of gestation).
- •In good health (Free of chronic diseases/acute diseases, full range of physical mobility)
排除标准
- •Women who are not pregnant
- •Women who are pregnant with more than one child
- •Women with history of spontaneous abortion, pre-term birth
- •Women who are not in good health or have metabolic, neurologic or immune disorders including; preeclampsia/eclampsia, gestational diabetes, pregnancy-related anemia, pregnancy- related jaundice.
- •Women who are substance dependent (i.e. alcohol, cigarette, illicit drugs)
- •Women allergic to egg/ egg protein
- •Women who have experienced severe nausea and vomiting throughout pregnancy
- •Women who are claustrophobic
结局指标
主要结局
13 Carbon dioxide production
时间窗: 8 hours
Urine, breath and a single blood sample will be collected during the study to measure the rate of oxidation of tracer in expired breath and flux by enrichment in urine.
次要结局
未报告次要终点
研究者
Rajavel Elango, PhD
Principle Investigator
University of British Columbia