Markers of Recovery in StrokE Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Establish plasma metabolite biomarkers that mirror neuronal repair and identify structural changes following ischemic strokes
研究概览
简要总结
Our current biological understanding of stroke recovery in humans is extremely limited and this lack of knowledge is a major challenge in reducing stroke disabilities and deficits. Evidence of neural repair in humans can be gleaned indirectly through functional outcome measures, but we propose that metabolomics may also provide a minimally invasive window into human brain repair. This study will integrate clinical imaging and molecular biomarkers as a diagnostic tool in further understanding stroke recovery mechanisms.
详细描述
Our long-term goal is to improve and hasten recovery following a stroke with translational research, which would combine the use of neuroimaging and identify neural repair metabolites. The objective and sequential step in fulfilling our long-term goal, is to identify differential expression of select stroke plasma biomarkers of neural repair, and image CST integrity in patients with good and poor recovery following an ischemic stroke. Diffusion tension imaging (DTI), will be used to image the neural repair as it occurs, further enhancing our understanding of stroke recovery. There are currently no known plasma biomarkers of neural repair. Identification of such biomarkers would be extremely valuable for designing stroke recovery drugs and timing rehabilitation therapies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Imaging confirmed ischemic stroke within 7 days of stroke onset
- •Age > 18 years
- •NIHSS ≥ 1 on arm item OR NIHSS = 0 on arm item but < 3/5 strength on MRC scale in distal joint (flex/ext elbow or grip/ext hand)
- •Pre-stroke modified Rankin Scale (mRS) < 3
排除标准
- •Active malignancy (not thought to be cured or in remission)
- •Anemia (HCT < 25)
- •Suspected bacterial endocarditis
研究组 & 干预措施
DTI Outcomes and Biomarkers
Imaging and Lab Collection
干预措施: DTI Images and Plasma Biomarkers (Other)
结局指标
主要结局
Establish plasma metabolite biomarkers that mirror neuronal repair and identify structural changes following ischemic strokes
时间窗: 2 years
Identify differential expression of select stroke plasma biomarkers of neural repair through metabolic testing and imaging CST integrity in patients with good and poor recovery following an ischemic stroke
次要结局
- Change in Fugl-Meyer(Baseline, 90 days post stroke)