Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 345
- 主要终点
- complications
研究概览
简要总结
Short-term studies have shown that patients with short bowel syndrome (SBS) often develop cholestasis or cholelithiasis. In this retrospective cohort study, we aimed to define the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended time period.
详细描述
However, only limited data are available regarding cholelithiasis in patients with SBS. The prevalence of cholelithiasis in patients with SBS has been reported only in two studies. Furthermore, few studies have focused on identifying the risk factors for cholelithiasis in patients with SBS. Considering the marked improvements in medical care and nutrition support during the last 2 decades, the current incidence and risk factors for cholelithiasis in patients with SBS are unknown.
The aim of the current study was to provide comprehensive, longitudinal, and long-term data on the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS, in order to identify the prevalence, risk factors, and clinical consequences of cholelithiasis in patients with SBS to aid in the development of protective interventions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All eligible adults diagnosed with SBS
排除标准
- •age <18 years; history of cholelithiasis before SBS diagnosis; cholecystectomy; biliary tract obstruction or no abdominal imaging (CT, MRI, or ultrasound) after SBS diagnosis.
结局指标
主要结局
complications
时间窗: 2010/1/1-2019/12/31
the clinical consequences of cholelithiasis in patients with SBS
the incidence of cholelithiasis in patients with SBS
时间窗: 2010/1/1-2019/12/31
the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with SBS
risk factors
时间窗: 2010/1/1-2019/12/31
the risk factors of cholelithiasis in patients with SBS
次要结局
未报告次要终点
研究者
Wang Xinying
Professor
Jinling Hospital, China