Enhancing Function in Later Life: Exercise and Functional Network Connectivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 317
- 试验地点
- 2
- 主要终点
- Cognitive Function
研究概览
简要总结
Physiological and neurocognitive changes experienced as a result of increasing age may influence socioemotional functioning and economic behaviors, yet, the mechanisms through which these changes occur are not well understood. Studies have also shown that aerobic exercise may protect against age-related cognitive decline in other domains. This research is designed to test the hypothesis that aerobic exercise will enhance social, emotional and economic functioning in older adults, and that these effects will occur via the effect of exercise on neurocognitive structure and function assessed via magnetic resonance imaging (MRI). Advancing our knowledge of the mechanisms that influence emotional, social and economic functioning could inform the development of targeted treatments and prevention programs for older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 25-35 for younger adults, and age 60 or over for older adults
- •Sedentary (i.e., < 60 minutes per week of moderate physical activity in the past 6-months)
- •Able to make fewer than 3 errors on the Pfeiffer Mental Status192
- •Willing to accept random assignment to condition (older adults)
- •Physically capable of safely engaging in moderate exercise activity (i.e., no injuries, physical impairments, or pre-existing contraindications) as assessed by a study physician
- •Able to successfully complete a maximal exercise test without evidence of cardiac or other abnormalities
- •Planning to remain in the Boulder-Denver metro area for the next 4 months (older adults)
排除标准
- •Are a heavy smoker (>20 pack years)
- •Are diabetic
- •Have a body size exceeding the capacity of the magnetic resonance imaging machine (approximately 23" in diameter)
- •Are on antipsychotic medications
- •Are currently under treatment for any psychiatric disorder, including clinical depression, Alzheimer's, or dementia
- •Are currently pregnant
- •Have magnetic resonance imaging contraindications (i.e., non-removable metallic implants, claustrophobia, traumatic brain injury, current pregnancy, etc.)
结局指标
主要结局
Cognitive Function
时间窗: 4 months
1. Functional connectivity is measured via having participants lie in a magnetic resonance imaging scanner and passively stare at a centrally-positioned fixation crosshair for 8 min while their brain activity is recorded. 2. Executive function will be measured with 3 tasks characterized by the three domains of executive function: updating, shifting, and inhibition. For updating, we will utilize the Keep Track task,for shifting, we will use the Category Switch Task, and for inhibition we will use the Stroop task.
次要结局
未报告次要终点
研究者
Angela Bryan
Professor
University of Colorado, Boulder