Obstructive Sleep Apnea in Asthmatic Children: Does the Sex Matter?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Sleep Apnea Syndrome
研究概览
简要总结
Asthma and sleep apnea are both respiratory diseases and one can worsen the other. Those who suffer from asthma have a higher risk of sleep apnea and sleep apnea can make the asthma more difficult to control.
As girls usually have a more severe asthma than boys, the investigators believe that girls have a higher risk of sleep apnea.
To test if asthmatic girls have more sleep apnea than boys, the investigators are going to ask them questions regarding asthma and sleep symptoms (such as snore) and the investigators are going test the lung function and how many times they stop breathing during the sleep. The sleep test is going to be performed in children's home.
In children, having sleep apnea can make the asthmatic stay in the hospital 30% more when they have an asthma attack. We also are going to look if sleep apnea increases the number of hospitalizations and asthma attacks in the past 12 months.
详细描述
Obstructive sleep apnea (OSA) and asthma are both inflammatory airway diseases. A systematic review regarding sleep-disordered breathing (SDB) in asthmatic children analyzed 17 studies but only two of them had objective OSA measurement. In total, 45,115 children were included, 53% boys, mean age 8.6 ± 2.5 years. SDB was present in 23.8% of asthmatic children and in 16.7% of non-asthmatic (p < 0.001, OR 1.9, 95%CI 1.7-2.2).
An American study found that OSA in asthmatic children increases hospital length of stay (OR 2.3; 95% CI = 1.8 - 2.9). Brazilian database of the year 2015 showed that, among children 5-19 years, asthma was the 5th cause of hospitalization: a total of 2.4% of the hospitalization in this age group, after birth and its complication (31%), limb fractures (5.7%), pneumonia (3.8%), and appendicitis (3.2%).
The relationship among asthma severity (mild, moderate, and severe) and OSA has been described previously, but not in every study. Poor asthma control has also been linked to a higher OSA risk in adults and children.
OSA and asthma share many risk factors: rhinitis, increased collapsibility of the upper airway, local and systemic inflammation, gastroesophageal reflux, and obesity.
A higher risk of SDB in asthmatic girls has recently been described (OR 2.55 for girls and 0.70 for boys). Among non-asthmatic children OSA is usually equal among boys and girls until adolescence. A possible explanation is asthma severity in children: younger boys are more severe but after puberty, girls are.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Persistent asthma
排除标准
- •Craniofacial malformation
- •Thoracic malformation
- •Genetic syndromes
- •Bronchopulmonary dysplasia
- •Bronchiolitis obliterans
- •Neuromuscular diseases
- •Sickle cell anemia
- •Cystic fibrosis
研究组 & 干预措施
Asthma
Children and teenagers with persistent asthma will perform questionnaires, lung function test, and home sleep study
干预措施: Questionnaire (Other)
Asthma
Children and teenagers with persistent asthma will perform questionnaires, lung function test, and home sleep study
干预措施: Lung Function Test (Other)
Asthma
Children and teenagers with persistent asthma will perform questionnaires, lung function test, and home sleep study
干预措施: Home Sleep Study (Other)
结局指标
主要结局
Sleep Apnea Syndrome
时间窗: 1 night
Apneas and hypopneas during sleep
次要结局
- ER visits(1 year)
- Lung function(1 day)
- Asthma Control(4 weeks)
研究者
Gustavo Antonio Moreira
Medical Doctor
Federal University of São Paulo