Rating Comparative Microbiology of Cell Populations Present Around Teeth Affected by Periodontal Disease and Implants Affected by Peri-implant Disease.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Peri-implant Microbiota
研究概览
简要总结
The purpose of the study was to evaluate, from a microbiological point of view, microbiota around teeth and implants in the same patient affected by periodontal disease and peri-implant disease, all compared with a healthy tooth. From the identification of particular bacterial species in the examined sites, it is intended to be traced back to the identification of a clear etiopathogenic process, which may shed light on the similarities and differences between the two diseases. In recognition of these mechanisms, the investigators think to develop new therapeutic strategies for the future.
详细描述
Harvested via sterile paper points, for endodontic use, the sulcular fluid present around a dental element affected by periodontitis, and, in the same patient, the fluid present inside a peri-implant sulcus of a implant affected periimplantitis. If more implants are considered affected by perimplantitis, partecipant will choose the worst as sample site. The same principle will be followed in the case of the tooth affected by periodontal disease. The samples must be underwent to bacterial genomic meta-analysis for the precise identification of bacterial. For a better comparation of the flora, even a healthy tooth from the same patient will be choose like test site and a gingival crevicular fluide will be harvested on it.
The investigators think that the perfect knowledge of the pathogen species is the starter point from a correct therapeutic strategy. But is really important take in mind the individual characteristcs of oral microflora.
The data to be noted at the outset are:
Signs and symptoms of periodontal disease, with precise framing within the Armitage 1999 Classification, and peri-implant disease. For the aim of the study definition of perimplantitis concern an implant with a 4 mm minimal probing depth with bleeding on probing and or suppuration (BOP and Supp) and radiographic bone loss (BL).
Evidence of BL recorded in order of definition of 8th European Consensus Conference of Periodontology Working group 4: BL > 2 mm from the expected bone level if a preliminary rx was absent; Rx 2-3 times the SD of the measurement record (1-1,5 mm) in case a preliminary rx was present.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 45 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Implant in service for at least one year without any technical GBR.
- •Only Implant inserted on native bone
- •Fill out a medical history form and a periodontal board dedicated to the event
排除标准
- •Post-extractive implant
- •Patients in subintrant systemic conditions that contraindicate the insertion of implants
- •Patients in the last three months have taken antibiotics or follow any therapy for the resolution of acute events.
- •Women who are pregnant or nursing or undergoing hormone therapies
结局指标
主要结局
Peri-implant Microbiota
时间窗: 1 day
bacterial population around implant affected by peri-implantitis
次要结局
- Microbiota in Peri-implantitis and periodontal disease(1 day)
研究者
Giovanni Barbagallo
Professor
Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele
