A Study Focused on the Microflora and Metabolomics of Crohn's Disease Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Oral microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
研究概览
简要总结
The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.
详细描述
This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •individuals who were clear and signed the informed consent.
- •Male and female.
排除标准
- •Any one who can not provide accurate information.
- •Any one who denies the study.
结局指标
主要结局
Oral microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
时间窗: 3 months
The results were based on the 16S rRNA sequencing
Sputum microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
时间窗: 3 months
The results were based on the 16S rRNA sequencing
Small intestinal microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
时间窗: 3 months
The results were based on the 16S rRNA sequencing
次要结局
- Metabolic difference of blood samples between active stage of Crohn's disease, remission of Crohn's disease and healthy controls(3 months)
研究者
Huanlong Qin
Professor
Shanghai 10th People's Hospital