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临床试验/NCT02744001
NCT02744001已完成不适用

Diet Study: The Reinforcing Value of Added Sugars

USDA Grand Forks Human Nutrition Research Center2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2016年4月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
44
试验地点
2
主要终点
Change in relative reinforcing value (RRV) of snacks as assessed by indicator

研究概览

简要总结

The purpose of this study is to determine how daily diet relates to eating choices.

详细描述

Despite the long-term emphasis on reducing intake of and added sugar, this behavioral change has been hard to instill amongst most of the population. Foods with added sugars are highly reinforcing and, as such, reducing their consumption in order to adhere to the dietary guidelines (DGA) may be difficult to maintain. Sugar produces effects similar to some drugs of abuse such as increased extracellular dopamine release in the nucleus accumbens shell resulting in a reinforcing effect. Reducing any reinforcing behavior can be challenging, but in terms of food, it is not known whether the reinforcing value of foods high in added sugar increases when access to these foods is reduced. If so, this would present a mechanistic barrier to meeting the DGA and making dietary changes in general. That the reinforcing value of a behavior (e.g., eating sugar) will be increased when the rate of that behavior is decreased has strong theoretical underpinnings in the "Disequilibrium Approach". This theory predicts that the circumstances of reinforcement are created or limited by changing baseline access. According to the Disequilibrium Approach, a response deficit will result in an increase in reinforcement. Applied to the proposed study, the Disequilibrium Approach would predict that lowering the consumption of dietary added sugar would increase the reinforcing value of foods high in added sugar. The Disequilibrium Approach has accurately predicted an increase in the relative reinforcing value (RRV) of snack foods among children. However, dietary changes would need to occur at the whole diet level for adults and children to meet the DGA for reducing added sugar intake. It is important to know if reducing added sugars at the whole-diet level results in increases in the reinforcing value of foods high in added sugars.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 39 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • BMI within 18.5-24.9 kg/m2 or BMI within 30.0-50.0 kg/m2
  • Willing to consent to study conditions
  • Habitually consume at least 10% of daily energy intake from added sugars

排除标准

  • BMI 25.0-29.9 kg/m2
  • Currently taking drugs that change hunger
  • Have an eating disorder
  • Current tobacco user
  • Have diabetes or heart disease
  • Pregnant, lactating or planning pregnancy
  • Low liking of all available study test foods
  • Allergy/aversion to any of the foods provided during the diet intervention

结局指标

主要结局

Change in relative reinforcing value (RRV) of snacks as assessed by indicator

时间窗: Baseline and 1 week

RRV of snacks will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to a high added sugar snack or low added sugar alternative.

次要结局

未报告次要终点

研究者

发起方
USDA Grand Forks Human Nutrition Research Center
申办方类型
Fed
责任方
Sponsor

研究点 (2)

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