Dose-response Relation Between the Development of a Refeeding-like Syndrome and Sodium Balance in Patients Undergoing Acute Abdominal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- sodium balance
研究概览
简要总结
The refeeding syndrome has been reported without any evidence of prolopnged semistarvation, thus being different from the traditional disease.
The investigators wanted to investigate, if sodium infusions could be part of the explanation.
详细描述
Background: Refeeding syndrome is conventionally connected to start of feeding after prolonged periods of semi-starvation and adaption. However, it is also described in acutely ill patients and in ICU patients without a history of adaption, but sometimes only defined as a drop in p-phosphate without clinical manifestations. The investigators hypothesize, that a positive sodium balance could induce the refeeding-like syndrome (RLS).
Method: Consecutive patients for acute, abdominal surgery were included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 yr
- •ready for acute surgery
- •able to understand and cooperate.
排除标准
- •pregnancy or breastfeeding
- •renal insufficiency (p-creatinine>400 micr mol/l)
- •re-operations
- •expected hospital stay < 24 hours.
结局指标
主要结局
sodium balance
时间窗: 7 days
correlation between sodium balance and occurrence of the refeeding syndrome
次要结局
- phosphate balance(7 days)
- plasma phosphate(7 days)
- urinary excretion of phosphate(7 days)
研究者
Jens Rikardt Andersen
Associate Professor, Primary Investigator
University of Copenhagen