Efficacy of amantadine on behavioural and emotional problems and impairment of executive functioning due to acquired brain injury to the frontal lobes: a series of single case experimental design studies. - Efficacy of amantadine in acquired brain injury.

GGZ Oost Brabant (Rosmalen)0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

试验速览

暂无简介。

•* Subjects have suffered acquired brain damage due to various aetiologies as verified by CT or MRI
•* Subjects suffer from emotional lability/irritability, aggressiveness, apathy as established through clinical observation and/or impairment of executive functioning as established by clinical judgement or on the basis of neuropsychological assesment.
•* Subjects are >3 months post injury
•* Subjects are 18 years or older
•* Written informed consent is given

•* Current drug addiction
•* Current psychoses
•* The current use of incompatible medications: methylphenidate, typical or atypical antipsychotics, combination diuretics (hydrochlorthiazide + potassium sparing diuretics) or Levodopa.
•* Pregnancy and lactation
•* Cardiac disease. Inclusion only after the consulting cardiologists consent
•* Refractory epilepsy
•* Kidney failure (eGFR<10 ml/min)
•* A history of gastric ulceration
•* Current glaucoma
•* Hypersensitivity to amantadine or any of the excipients
•. Suicidality

发起方

GGZ Oost Brabant (Rosmalen)