The Effects of Hydration on Brain, Cognition, Memory & Achievement in Childhood
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Flanker Task Accuracy
研究概览
简要总结
The aim of this study is to determine the influence of changes in water intake on changes in cognitive function among preadolescent children. Further, the proposed work will determine the relationship between urinary markers of hydration process and cognitive function. We hypothesize that an increase in water intake will result in greater cognitive performance. In addition, improvements in hydration demonstrated by lower urine concentration will be correlated with greater cognitive performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 9 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Parental/guardian consent
- •Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task (below 20/20 vision).
排除标准
- •Participants younger than 9 years and older than 10 years at the time of testing age.
- •Prior diagnosis of cognitive or physical disability, including ADHD (severe asthma, epilepsy, chronic kidney disease, and dependence upon a wheelchair/walking aid).
- •Use of anti-psychotic, anti-depressant, anti-anxiety medication, as well as those medications used for ADD/ADHD (use of any anti-psychotic, anti-depressant, anti-anxiety, and ADD/ADHD medications).
- •Participants must have not yet reached, or be in the earliest stages, of puberty, as measured by a modified test of the Tanner Staging System
- •IQ below 85
- •Use of medications that alter urinary excretion and water metabolism
- •Use of internal electronic device, such as a pacemaker
研究组 & 干预措施
HIGH
Increase water intake to 2.5 liters per day for 4 days
干预措施: Water Intake (Behavioral)
LOW
Decrease water intake to 0.5 liter per day for 4 days
干预措施: Water Intake (Behavioral)
结局指标
主要结局
Flanker Task Accuracy
时间窗: 2 Hours on the morning of Day 5
次要结局
- Urine Osmolality(24 hours during final day of fluid intake modulation (Day 4))
研究者
Naiman Khan
Assistant Professor
University of Illinois at Urbana-Champaign