Hypo-hydration, Mood and Cognition: the Effect of the Colour and Type of Drink
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Swansea University
- Enrollment
- 162
- Locations
- 2
- Primary Endpoint
- Mood rating: agreeable / hostile
Study Overview
Brief Summary
Recently changes in mood and cognition have been reported following minor reductions in hydration status. The aim is to explore that such changes in part at least reflect placebo response; therefore the consumption of plain or coloured water will be compared in drinks designed to differ in their ability to rehydrate.
Detailed Description
162 individuals will be subject to a temperature of 30°C for three hours, and mood and cognition monitored. Randomly on two occasions they will consume no drink or 300ml of plain or red colored water. In addition they will take a capsule containing sodium chloride or a placebo. Mood will be monitored using visual analogue scales and a battery of cognitive tests will be completed on three occasions: attention, episodic and working memory, reactions times. Urine osmolality will be measured at the beginning and end of the study and changes in body mass will be recorded. Changes in functioning will be related to the nature of the drink and changes in osmolality and body mass.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Masking Description
Salt / placebo will be consumed by capsule under a double-blind procedure
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18 to 30 years
- •Non-smokers
- •BMI < 30
- •By self-report in good health
- •Not taking medication for any psychological or other health disorder.
Exclusion Criteria
- •Do not meet inclusion criteria
Arms & Interventions
Sodium chloride / Water
300mg sodium chloride consumed in a capsule on two occasions with 300ml water
Intervention: Salt with / without water (Biological)
Sodium chloride / no water
300 mg sodium chloride consumed
Intervention: Salt with / without water (Biological)
Sodium chloride / colored water
300mg sodium chloride consumed in a capsule on two occasions with 300ml coloured water
Intervention: Salt with / without water (Biological)
Placebo / water
Placebo consumed in a capsule on two occasions with 300ml water
Intervention: Salt with / without water (Biological)
Placebo / no water
Placebo capsule consumed
Intervention: Salt with / without water (Biological)
Placebo / coloured water
Placebo consumed in a capsule on two occasions with 300ml colored water
Intervention: Salt with / without water (Biological)
Outcomes
Primary Outcomes
Mood rating: agreeable / hostile
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words agreeable/hostile and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Mood rating: tired / energetic
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words tired / energetic and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Mood rating: confused / clearheaded
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words confused / clearheaded and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Mood rating: composed / anxious
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words composed / anxious and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Mood rating: depressed / elated
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words depressed / elated and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Mood rating: confident / unsure
Time Frame: Changes from baseline after 90 and 180 minutes
A hundred millimetre lines will be anchored with the words confident / unsure and the subject will rate their mood by marking the line.. My measuring in millimetres a score between 0 and 100 will result with a higher score indicating a more positive mood.
Secondary Outcomes
- Reaction times(Changes from baseline after 90 and 180 minutes)
- Serial Sevens; test of working memory(Changes from baseline after 90 and 180 minutes)
- Episodic memory(Changes from baseline after 90 and 180 minutes)
- Attention: Arrow Flankers(Changes from baseline after 90 and 180 minutes)
Investigators
David Benton
Professor
Swansea University