NCT02885558已完成不适用
Role of T-type Calcium Channels in Vascular Function
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Vascular function
研究概览
简要总结
The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 20 - 30 and 60-70
- •BMI < 30
排除标准
- •Hypertension (>150/90 mmHg)
- •Physical activity >2 hours/week
- •Known chronic diseases
- •Pregnancy or birth within 3 month
- •Alcohol misuse
研究组 & 干预措施
L + T-type
Experimental
8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)
干预措施: Efonidipine (Drug)
L-Type
Active Comparator
8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)
干预措施: Nifedipine (Drug)
结局指标
主要结局
Vascular function
时间窗: 8 weeks
Hemodynamic response to femoral arterially infused vasoactive substances
次要结局
未报告次要终点
研究者
Stefan Mortensen
Associate Professor
University of Southern Denmark
研究点 (2)
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