The neural substrate of cognitive and social-emotional apathy in patients with schizophrenia - The neural substrate of apathy in schizophrenia

niversitair Medisch Centrum Groningen0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Patients with schizophrenia (N=60)
•- At least 18 years of age
•- DSM-IV diagnosis of schizophrenia, or schizoaffective disorder
•- High levels of cognitive or social-emotional apathy
•- Absence or low level of apathy
•- Patient groups will be matched on age, sex, education, levels of depressive symptoms, levels of D2 dopamine receptor occupancy and handedness
•- Written informed consent;Healthy controls (N=20)
•- At least 18 years of age
•- Matched to patients on age, sex, education, levels of depressive symptoms and handedness
•- Written informed consent

•Patients with schizophrenia (N=60)
•Presence of a substance dependence disorder
•Presence of a neurological disorder
•Use of medication that can influence task results (e.g. beta-blockers, insulin);Healthy controls (N=20)
•Presence of a neurological or psychiatric disorder, in present or past.
•Use of medication that can influence task results (e.g. psychopharmaca, beta-blockers, insulin)
•High levels of apathy (a score of more than 27 on the AES);All subjects (N=80):
•Visual or hearing problems that cannot be corrected
•Insufficient knowledge of the Dutch language
•Inability to undergo cognitive testing

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