Risk of Aspergillus Infection in Patients With Chronic Structural Lung Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 209
- 试验地点
- 1
- 主要终点
- The area under ROC curve of risk factors for aspergillus pneumonia
研究概览
简要总结
Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined.
详细描述
Patients with chronic lung disease were identified as positive for Aspergillus fumigatus through sputum microscopy. According to diagnostic criteria, patients diagnosed with IPA and CPA and were assigned to the Aspergillosis pneumonia group, while the remaining patients were included in the Aspergillus colonization group. Then,Risk factors for aspergillus pneumonia, invasive pulmonary aspergillus disease, and chronic pulmonary aspergillus disease, such as the use of high-dose corticosteroids, inhaled corticosteroids, and the extent of damage to basic lung structures, were identified by comparing the aspergillus colonization group with the aspergillus infection group.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age : at least 18 years old ;
- •Imageological examination : Patients who complete high-resolution computed tomography (HRCT) images of the chest;
- •Serological examination : Patients who complete serological test results, including serum aspergillus specific IgG antibody, serum aspergillus IgM antibody and GM antigen detection.
排除标准
- •immunodeficiency conditions : Patients diagnosed with HIV infection, hematological malignancies, and autoimmune diseases.
- •Critically ill patients : Those who require mechanical ventilation in the ICU and have established various types of cardiopulmonary bypass.
- •Inadequate Clinical Data: Inability to provide reliable diagnostic measurements or insufficient clinical information.
结局指标
主要结局
The area under ROC curve of risk factors for aspergillus pneumonia
时间窗: Statistical analysis was carried out after data collection within two month
The area under ROC curve (AUC) was used to evaluate the classification effect of the binary classification model among Aspergillus pneumonia group, IPA group and CPA group
Descriptive statistical index
时间窗: Information was collected on the day of admission
Summarize participant characteristics using means and standard deviations for continuous variables and frequencies for categorical variables
Independent risk factor for aspergillus pneumonia
时间窗: Statistical analysis was carried out after data collection within one month
Independent risk factors for aspergillus infection were determined by multivariate logistic regression analysis.
次要结局
- Threshold analysis of aspergillus pneumonia(Statistical analysis was carried out after data collection within two month)
研究者
Lin Chen
professor
Sichuan Provincial People's Hospital