Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,711
- 试验地点
- 1
- 主要终点
- Incidence of postoperative delirium
研究概览
简要总结
This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing clinically relevant safety evidence for perioperative antibiotic decision-making and delirium prevention strategies.
详细描述
This prospective, observational, single-center cohort analysis was a substudy of the Perioperative Database of Chinese Elderly Patients (PDCEP) study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients over 65 years old
- •patients undergoing elective non-cardiac surgery
排除标准
- •older adult patients who had history of psychotic disorders
- •history of neurological disease
- •conditions that would make assessments for delirium unreliable
- •preoperative infection
- •severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery
- •missing data exceeding 5%, and no medication records
研究组 & 干预措施
Antibiotic
干预措施: Perioperative antibiotics exposure (Drug)
结局指标
主要结局
Incidence of postoperative delirium
时间窗: Participants will be followed for the duration of hospital stay, an expected average of 7 days.
Evaluations are conducted twice a day.
次要结局
未报告次要终点
研究者
Hao Li
Associate professor
Chinese PLA General Hospital