The First Affiliated Hospital of Chongqing Medical University.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- ST-segment resolution<40.15%
研究概览
简要总结
Clinical studies found that poor ST-segment resolution (STR) in electrocardiogram (ECG) occurred in major adverse cardiovascular events (MACE), arrhythmia and heart failure was significantly higher . In clinical work, in patients have poor ST-segment decline, the investigators found by CMR-LGE the corresponding myocardium become thinner and other signs of myocardial scar.
The investigators aimed to establish whether poor ST-segment resolution in ECG, as well as CMR-LGE, could detect the presence of myocardial scar in early STEMI patients. In order to provide convenient, cheap and widely used test method for patients who cannot tolerate CMR-LGE.
42 STEMI patients with single-branch coronary artery stenosis or occlusion were enrolled. ST-segment elevations were measured on the baseline and 24 hours after PCI. The study population was divided into two groups by late gadolinium enhanced cardiac magnetic resonance (LGE- CMR), with transmural myocardial scar (>75%) or non-transmural myocardial scar (<75%).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single-branch coronary artery stenosis or occlusion
- •Restoration of coronary perfusion to TIMI flow grade 3 after PCI
排除标准
- •A prior history of the acute coronary syndrome
- •Coronary revascularization
- •Severe chronic kidney disease
- •Intracardiac pacing leads or other implants precluding CMR-LGE
- •Hemodynamic instability
- •Known claustrophobia
结局指标
主要结局
ST-segment resolution<40.15%
时间窗: 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.
CMR-LGE was performed to evaluate myocardial scars.
ST-segment resolution>40.15%
时间窗: 1) Emergency admission: ST-segment elevations were measured. 2) 24 hours after PCI: ST-segment elevations were measured. 3) 7 days after PCI: CMR-LGE was performed.
CMR-LGE was performed to evaluate myocardial scars.
次要结局
未报告次要终点
研究者
Dongying Zhang
Clinical Professor
First Affiliated Hospital of Chongqing Medical University