The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- The perioperative alternation of the venous blood total antioxidant capacity levels of the arms
研究概览
简要总结
The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.
Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II physical status
- •Unilateral total knee arthroplasty
- •Age 18 years to 80 years
排除标准
- •Severe central nervous system disorders
- •Severe cardiopulmonary,renal,metabolic, or hepatic disease,
- •Blood volume deficits,
- •Coagulopathy,
- •Allergy to local anesthetics,
- •Peripheral neuropathies,
- •Body mass index > 35,
- •History of antioxidant drug use
研究组 & 干预措施
Propofol
Propofol infusion group: Under spinal anesthesia, a continuous intravenous infusion (2mg/kg/h) of propofol will be use during the operation
干预措施: Propofol (Drug)
Control group
Placebo group: Under spinal anesthesia, a continuous intravenous infusion of volume-equivalent placebo will use during the operation
干预措施: Placebo (Drug)
结局指标
主要结局
The perioperative alternation of the venous blood total antioxidant capacity levels of the arms
时间窗: T1,T2,T3
T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation
次要结局
未报告次要终点
研究者
derya özkan
Consultant MD of Anesthesiology Department
Diskapi Teaching and Research Hospital