Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Phase 4

Completed

• Conditions: Obesity; Anesthesia
• Interventions: Drug: Desflurane Inhalant Product; Drug: Propofol

• Registration Number: NCT03417518
• Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Brief Summary

Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.

Detailed Description

Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2015-01
• Primary Completion: 2015-10
• Study Completion: 2016-09
• Study First Submitted: 2018-01-25
• Study First Submitted QC: 2018-01-25
• Study First Posted: 2018-01-31
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-08
• Last Update Posted: 2018-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Body Mass Index (BMI) >35
• scheduled gastric by pass surgery
• American Society of Anesthesiologists (ASA) <III

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Exclusion Criteria

• Allergic to anesthesia agent
• patient refusal

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane Inhalant Product Group	Desflurane Inhalant Product	general anesthesia with desflurane
Propofol Group	Propofol	general anesthesia with propofol

Primary Outcome Measures

Name	Time	Method
Malondialdehyde (MDA) level in blood sample	up to 24 hours post bariatric surgery	Plasma MDA level is measured as an oxidative stress marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.

Secondary Outcome Measures

Name	Time	Method
Pain assessed by Visual Analog Scale (VAS)	up to 48 hours after surgery	Pain level is determined at 2 hours, 24 hours and 48 hours post-surgical incision. Visual analog pain score (scale = 0 no pain; 10= worst pain imaginable)
Side-effects (nausea, vomiting, somnolence, respiratory depression)	up to 48 hours after surgery	Evaluation at 2 hours, 24 hours and 48 hours post-surgical incision
C-Reactive Protein (CRP) in blood sample	up to 24 hours post bariatric surgery	Plasma CRP level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.
Monocyte level in blood sample	up to 24 hours post bariatric surgery	Monocyte level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.