Effects of General Anesthesia With Propofol Versus Desflurane on Oxidative Stress and Inflammation in Obese Patients Scheduled for Bariatric Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Malondialdehyde (MDA) level in blood sample
研究概览
简要总结
Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.
详细描述
Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Body Mass Index (BMI) >35
- •scheduled gastric by pass surgery
- •American Society of Anesthesiologists (ASA) <III
排除标准
- •Allergic to anesthesia agent
- •patient refusal
研究组 & 干预措施
Desflurane Inhalant Product Group
general anesthesia with desflurane
干预措施: Desflurane Inhalant Product (Drug)
Propofol Group
general anesthesia with propofol
干预措施: Propofol (Drug)
结局指标
主要结局
Malondialdehyde (MDA) level in blood sample
时间窗: up to 24 hours post bariatric surgery
Plasma MDA level is measured as an oxidative stress marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.
次要结局
- Pain assessed by Visual Analog Scale (VAS)(up to 48 hours after surgery)
- Side-effects (nausea, vomiting, somnolence, respiratory depression)(up to 48 hours after surgery)
- C-Reactive Protein (CRP) in blood sample(up to 24 hours post bariatric surgery)
- Monocyte level in blood sample(up to 24 hours post bariatric surgery)