Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 主要终点
- Evidences of Clinically Definite Oxidative Stress Confirmed by High Performance Liquid Chromatography
研究概览
简要总结
The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.
详细描述
intracranial aneurysm surgery may lead to regional ischemic reperfusion injury. Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats.
As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis intracranial aneurysm surgery ,
- •American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ.
排除标准
- •severe hepatic and renal dysfunction
- •coagulation disorder
- •taking antioxidant perioperative period
研究组 & 干预措施
sevoflurane
0.5%-2% sevoflurane
干预措施: sevoflurane (Drug)
propofol postconditioning
1.2mg/L propofol
干预措施: propofol postconditioning (Drug)
propofol postconditioning
1.2mg/L propofol
干预措施: sevoflurane (Drug)
结局指标
主要结局
Evidences of Clinically Definite Oxidative Stress Confirmed by High Performance Liquid Chromatography
时间窗: before induction,after clamping removal ,operation ending ,1,3,7days post surgery
Evidences of clinically definite oxidative stress :α- tocopherol,γ- tocopherol which was used to assess the antioxidant defense.
Evidences of Clinically Definite Oxidative Stress Confirmed by ELISA Kit
时间窗: before induction,after clamping removal ,operation ending ,1,3,7days post surgery
Evidences of clinically definite oxidative stress :Superoxide dismutase activity, Hydroxyl radical
Evidences of Clinically Definite Oxidative Stress:Micronuclei
时间窗: before induction,clamping removal ,operation ending,1,3,7days post surgery
Evidences of clinically definite oxidative stress:micronuclei confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress: Nuclear Buds
时间窗: before induction,clamping removal ,operation ending,1,3,7days post surgery
Evidences of clinically definite oxidative stress:nuclear buds Confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress: Nucleoplasmic Bridges
时间窗: before induction,clamping removal ,operation ending,1,3,7days post surgery
Evidences of clinically definite oxidative stress: nucleoplasmic bridges confirmed by Cytokinesis-block Micronucleus Test
Evidences of Clinically Definite Oxidative Stress Confirmed by ELISA
时间窗: before induction, after clamping removal,operation ending,1,3,7days post surgery
Evidences of clinically definite oxidative stress:8-isoprostane,as a reliable biomarkers of lipid peroxidation
次要结局
- Montreal Cognitive Assessment (MoCA)(before induction,1,3,7days post surgery)
- Mini Mental State Examination (MMSE)(before induction,1,3,7days post surgery)