NCT00765596已完成不适用
Ghrelin Changes After Roux-en-Y Gastric Bypass: Does Gastric Pouch vs. Gastric Remnant Feeding Affect Secretion?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Ghrelin
研究概览
简要总结
The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Serum creatinine and liver function tests < upper limits of normal
- •Stable body weights for the past three months
- •Women will have a negative pregnancy test
- •patients who are already scheduled for RYGB with gastrostomy tube placement
排除标准
- •Significant hepatic enzyme elevations (more than 100% of upper limits of normal)
- •Serum creatinine > 1.5 mg/dl
- •history of ketoacidosis or current metabolic acidosis
- •current use of oral anticoagulants
- •Positive pregnancy test (beta-human chorionic gonadotrophin) for females
- •intercurrent infections
- •patients with prior gastric operations
结局指标
主要结局
Ghrelin
时间窗: pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op
次要结局
- HOMA(pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op)
- metabolic hormones(pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op)
研究者
Naji Abumrad
Chairman, Department of Surgery
Vanderbilt University
研究点 (1)
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