Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Changes in Cardiac fat volumes
研究概览
简要总结
Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
详细描述
Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI 30-39.99
- •White/Caucasian
排除标准
- •Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded.
- •Pregnant females.
- •Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study.
- •Participants that exercise more than three times per week or strength train more than twice per week.
- •Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded.
- •Cigarette smoking (current or those who quit within the previous 6 months
- •Hypertension
- •Diabetics
- •MRI exclusion criteria must be observed: must complete a safety checklist that is designed to identify metal in your body that could pose a hazard during scanning. Some forms of metal are acceptable (e.g., dental fillings after 1970). Tattoos are generally not exclusionary, unless they have been inked with metallic dyes. All metal must be removed from your body. All female subjects, prior to scanning, are required to complete a pregnancy test. Must NOT be claustrophobic or have a history of claustrophobia
结局指标
主要结局
Changes in Cardiac fat volumes
时间窗: 2 assessment points: at baseline and week 4
Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging
次要结局
- Changes in Cardiorespiratory Function(2 assessment points: at baseline and week 4)
- Changes in Vascular function(2 assessment points: at baseline and week 4)
- Changes in Muscular Strength(2 assessment points: at baseline and week 4)
- Changes in Body Composition(2 assessment points: at baseline and week 4)
- Changes in Diet(5 assessment points: baseline, week 1, 2, 3, and 4)
- Changes in Spontaneous Physical Activity(Baseline and week 4)
- Changes in Oxidative stress markers(5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4.)