Establishing Evidence-based Multicomponent Treatment for Speech and Language in Primary Progressive Aphasia
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Change in script production accuracy
研究概览
简要总结
The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.
The main questions the study aims to answer are:
- Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?
- Do participants with PPA and care partners report satisfaction with the program?
- Which outcome measures are most useful for evaluating changes in communication and quality of life?
- What patterns of treatment response are seen in participants after completing the program?
Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.
Participants will:
- Take part in online speech-language therapy sessions
- Complete communication tasks and questionnaires before and after the program
- Have regular virtual check-ins with the research team
- Include their care partners in some parts of the program for training and support
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
- •Scores of 10 or higher on the Mini-Mental State Examination
- •Has a study partner who can consistently attend sessions
排除标准
- •Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
- •Significant, uncorrected visual or hearing impairment that would interfere with participation
- •Score of less than 10 on the Mini-Mental State Examination
- •Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)
结局指标
主要结局
Change in script production accuracy
时间窗: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Percent correct intelligible, scripted words for trained/untrained scripts
Change in spoken naming of trained/untrained items
时间窗: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Percent correctly named trained/untrained pictures
Information communicated in any modality for trained/untrained stimuli
时间窗: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
Percent of major content units (key words) communicated via speech or nonspeech modalities (e.g., writing, drawing, gesture) for trained/untrained scripts (Multi-VISTA) or words (Multi-LRT) during structured probes and in conversation
Goal Attainment Score
时间窗: change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
The Goal Attainment Score is self-reported progress on personalized goals based on a five point scale.
次要结局
- Change on Quick Aphasia Battery(change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment)
- Change on Aphasia Impact Questionnaire(change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment)
研究者
Maya Henry
Associate Professor
University of Texas at Austin