Effect of Chemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases. A Single-centre Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 主要终点
- Survival
研究概览
简要总结
Retrospective analysis of a prospectively collected database of 170 patients between 2004 and 2020, who underwent liver resections for CRLM (colorectal liver metastases) at The Queen Elizabeth Hospital trying to determine rates and patterns of recurrence following liver resections for CRLM and concurrently, characterise clinical, pathological and treatment-related factors that could function as predictors of recurrence or survival, particularly neoadjuvant chemotherapy and tumour clearance.
详细描述
This is a descriptive, observational study with retrospective analysis of a prospectively collated database. This database included all patients who underwent curative hepatic resections for CRLM (colorectal liver metastases) at The Queen Elizabeth Hospital (Adelaide, Australia) between December 2004 and October 2020.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent a liver resection for CRLM at The Queen Elizabeth Hospital between December 2004 to September 2020
排除标准
- •Patients whose procedures were abandoned due to unresectable tumour burden
结局指标
主要结局
Survival
时间窗: From surgery to death or end of the study, up to 16 years
up to16 years
Recurrence
时间窗: From surgery to recurrence, up to 16 years
Recurrence rate
次要结局
- Resection margins(From surgery to death or end of the study, up to 16 years)
- Neoadjuvant Chemotherapy(From surgery to death or end of the study, up to 16 years)
研究者
Mauro Andres Perdomo, MD, MHA
MD, General Surgeon
Hospital Maciel