Ticagrelor-Based Dual Antiplatelet Therapy in Coronary Artery Bypass Grafting: A Randomized Clinical Trial on Graft Patency
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Saphenous Vein Graft (SVG) Patency at 12 Months
研究概览
简要总结
This randomized controlled trial aims to evaluate the impact of different durations of Ticagrelor-based dual antiplatelet therapy (DAPT) on saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass grafting (CABG). A total of 300 patients will be randomly assigned to receive Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, 6 months, or 12 months, followed by aspirin monotherapy.The primary outcome is 1-year graft patency, assessed via coronary CT angiography. Secondary outcomes include bleeding events (BARC classification), major adverse cardiovascular and cerebrovascular events (MACCE), and all-cause mortality. The study aims to determine the optimal DAPT duration to balance graft patency benefits and bleeding risks, ultimately guiding postoperative antiplatelet strategies for CABG patients.
详细描述
Coronary artery bypass grafting (CABG) is a widely used revascularization strategy for patients with complex coronary artery disease. However, the long-term patency of saphenous vein grafts (SVGs) remains a significant clinical concern, with graft occlusion being a major contributor to recurrent ischemic events. Dual antiplatelet therapy (DAPT), consisting of Ticagrelor and Aspirin, is commonly used to prevent thrombosis and improve graft patency, yet the optimal duration of DAPT post-CABG remains unclear. This randomized, double-blind, controlled trial aims to assess the effects of different DAPT durations on SVG patency and clinical outcomes in CABG patients. A total of 300 patients undergoing isolated CABG with at least one SVG will be enrolled and randomly assigned (1:1:1) to receive Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, 6 months, or 12 months, followed by aspirin monotherapy. The primary outcome of the study is SVG patency at 12 months, assessed via coronary CT angiography, defined as FitzGibbon Grade A (≤50% stenosis). Secondary outcomes include bleeding events , major adverse cardiovascular and cerebrovascular events (MACCE), and all-cause mortality. Patients will be followed at 3, 6, and 12 months postoperatively, undergoing clinical assessments, laboratory tests, and imaging evaluations to monitor graft patency, bleeding complications, and cardiovascular and cerebrovascular events. The study will provide critical data to determine the optimal duration of DAPT to maximize graft patency while minimizing bleeding risks, ultimately guiding personalized antiplatelet strategies in CABG patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients 18-80 of age.
- •Patients undergo planned CABG for the first time with ≥1 SVGs
- •Patients with written informed consent.
排除标准
- •Patients undergoing concomitant valve surgery (excluding aortic bioprosthesis), aortic surgery, or rhythm surgery during the same session.
- •Patients undergoing emergency CABG.
- •Patients with single-vessel coronary artery disease.
- •Patients with cardiogenic shock or hemodynamic instability.
- •Patients with sick sinus syndrome, second- or third-degree atrioventricular block.
- •Patients with contraindications for coronary computed tomography angiography (CCTA) or coronary angiography, including contrast media allergy.
- •Patients requiring antiplatelet therapy other than aspirin or ticagrelor (e.g., clopidogrel, prasugrel) and unable to discontinue such medication after CABG, based on physician or investigator judgment.
- •Patients on oral anticoagulants before CABG who must continue anticoagulation therapy postoperatively.
- •Patients with contraindications for ticagrelor or aspirin, including:
- •9.1Bleeding diathesis within the past 3 months. 9.2Severe gastrointestinal bleeding within the past year. 9.3Peptic ulcer (even without bleeding) within the past 3 years. 9.4History of intracranial hemorrhage, aspirin allergy, or severe aspirin-induced gastrointestinal reaction.
- •Patients with a drug-eluting stent (DES) in a coronary or cerebral artery within 6 months before CABG, or a bare-metal stent (BMS) within 1 month before CABG.
- •Patients with thrombocytopenia (<100 x 10⁹/L) before CABG.
- •Patients with severe renal dysfunction requiring dialysis or active liver disease, including unexplained persistent transaminase elevation or transaminase levels >3× the upper normal limit.
- •Patients using strong CYP3A4 inhibitors.
- •Patients requiring methotrexate and ibuprofen therapy.
- •Patients with active malignant tumors with an increased risk of bleeding, as determined by the investigator.
- •Pregnant or breastfeeding women, and those who have given birth within the past 90 days.
- •Premenopausal women not using adequate contraception. Adequate contraception requires at least two reliable methods, including one barrier method.
研究组 & 干预措施
3-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, followed by aspirin monotherapy
干预措施: Ticagrelor + Aspirin for 3 Months (followed by aspirin monotherapy) (Drug)
6-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 6 months, followed by aspirin monotherapy
干预措施: Ticagrelor + Aspirin for 6 Months (followed by aspirin monotherapy) (Drug)
12-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 12 months, followed by aspirin monotherapy
干预措施: Ticagrelor + Aspirin for 12 Months (followed by aspirin monotherapy) (Drug)
结局指标
主要结局
Saphenous Vein Graft (SVG) Patency at 12 Months
时间窗: 12 months post-CABG
SVG patency will be assessed using coronary CT angiography, defined as FitzGibbon Grade A (≤50% stenosis). The patency rates will be compared among the three groups receiving Ticagrelor-based DAPT for different durations (3 months, 6 months, or 12 months).
次要结局
- Bleeding Events(Up to 12 months post-CABG)
- MACCE episodes(Within 1-year after CABG)
- All-Cause Mortality(Up to 12 months post-CABG)
研究者
Kexiang Liu, MD
Principal Investigator
Second Hospital of Jilin University