Evaluating the Effect of Desflurane Versus Sevoflurane With Recent Biomarkers of Renal and Hepatic Function in Laparoscopic Cholecystectomy Patients: A Prospective Randomized Double Blinded Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Change in serum Neutrophil gelatinase-associated lipocalin (NGAL)
研究概览
简要总结
Studying the effects of both inhalational anesthetics desflurane and sevoflurane on hepatic integrity and renal function, guided by recent blood and urine biomarkers in patients undergoing laparoscopic cholecystectomy surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) Class: I&II.
- •Elective laparoscopic cholecystectomy.
- •Age: 25-55 years.
- •Gender: Both male and female.
- •Body Mass Index (BMI): 18.5-24.9 km2-(Normal weight).
排除标准
- •Extremes of age.
- •Abnormal hepatic function by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values outside the normal range.
- •Abnormal renal function by blood urea nitrogen (BUN) and creatinine above the normal ranges.
- •Hypertension, unstable angina pectoris or myocardial infarction within the last six months.
- •Pregnancy and lactation.
- •Bronchial asthma.
- •Drug allergies.
- •Alcohol or drug addiction.
- •General anesthesia within the last three months.
研究组 & 干预措施
Sevoflurane
This group will receive sevoflurane as the maintenance inhalational anesthetic.
干预措施: Sevoflurane (Drug)
Sevoflurane
This group will receive sevoflurane as the maintenance inhalational anesthetic.
干预措施: Neutrophil Gelatinase-Associated Lipocalin (NGAL) (Diagnostic Test)
Desflurane
This group will receive desflurane as the maintenance inhalational anesthetic.
干预措施: Neutrophil Gelatinase-Associated Lipocalin (NGAL) (Diagnostic Test)
Desflurane
This group will receive desflurane as the maintenance inhalational anesthetic.
干预措施: Desflurane (Drug)
结局指标
主要结局
Change in serum Neutrophil gelatinase-associated lipocalin (NGAL)
时间窗: a change from baseline NGAL serum level at 6 hours
Renal Biomarker
次要结局
- Change in serum Arginase(Baseline, first hour, six hours, after 24 hours)
- Change in serum Cystatin-c(Baseline, first hour, six hours, after 24 hours)
- Change in urine Interleukin-18(Baseline, first hour, six hours, after 24 hours)
- Change in urine Netrin-1(Baseline, first hour, six hours, after 24 hours)
- Change in urine Kidney Injury Molecule(Baseline, first hour, six hours, after 24 hours)
- Change in urine Alpha-Glutathione S-Transferase(Baseline, first hour, six hours, after 24 hours)
研究者
khalda Galal Moustafa
Principal Investigator
Theodor Bilharz Research Institute