Clinical, Histological and Prognostic Forms of Adenocarcinoma of the Anus
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 46
- 试验地点
- 2
- 主要终点
- Risk of mortality at 1 year, estimated using a survival curve
研究概览
简要总结
Adenocarcinoma of the anus is rare. It concerns less than 10% of anal cancers and its incidence is less than 0.2/100 000 inhabitants. Its management is not consensual and is most often derived by analogy with that of adenocarcinoma of the lower rectum. This is due to the rarity but also to the diversity of anatomical (anal margin, anal canal, lower rectum), etiological (primary glandular tumors or secondary to anal fistula, primary distant tumor and/or Crohn's disease) and histological forms (mucinous, intestinal, glandular adenocarcinomas and primary or secondary Paget's disease). Most of the literature consists of small case series and simple clinical cases in which the prognosis of these subforms has not been studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient over 18 years of age
- •French-speaking patient
- •Patient with a diagnosis of adenocarcinoma of the anus between 01/01/2006 and 30/06/2022 in participating centers
排除标准
- •Patient under guardianship or curatorship
- •Patient deprived of liberty
- •Patient under court protection
- •Patient objecting to the use of his data for this research
结局指标
主要结局
Risk of mortality at 1 year, estimated using a survival curve
时间窗: Year1
This outcome corresponds to the 1 year mortality rates after diagnosis of adenocarcinoma of the anus.
Risk of mortality at 5 years, estimated using a survival curve
时间窗: Year5
This outcome corresponds to the 5 year mortality rates after diagnosis of adenocarcinoma of the anus.
次要结局
- Search for prognostic factors of severity in all forms(Year5)
- Adaptaion of the therapeutic management according to the clinical and histological form(Year5)
- Describe the various anatomical, etiological and histological forms(Year5)
- Describe their therapeutic management(Year5)
- Compare prognosis by clinical and histological form(Year5)