Effect of Inulin and Resistant Starch on Postprandial Short Chain Fatty Acid, Glucose, Insulin and Gut Hormone Responses in Lean and Overweight Subjects.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 主要终点
- Incremental area under the serum acetate response curve
研究概览
简要总结
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-pregnant
- •body mass index >=20 and <=35
排除标准
- •history of diabetes mellitus
- •history of cardiovascular disease
- •history of bowel disease
- •history of kidney disease
- •history of liver disease
- •use of antibiotics within 3 months of enrolment
- •unusual dietary habits
- •fasting glucose >6.9mmol/L
- •hematocrit below normal range for age and sex
结局指标
主要结局
Incremental area under the serum acetate response curve
时间窗: For 6 hours after consuming the test meal
次要结局
- Incremental area under the serum propionate response curve(For 6 hours after consuming the test meal)
- Incremental area under the breath methane response curve(For 6 hours after consuming the test meal)
- Incremental area under the serum insulin response curve(For 2 hours after consuming the standard lunch)
- Incremental area under the serum butyrate response curve(For 6 hours after consuming the test meal)
- Incremental area under the breath hydrogen response curve(For 6 hours after consuming the test meal)
- Incremental area under the serum c-peptide response curve(For 2 hours after consuming the standard lunch)
- Incremental area under the serum glucose response curve(For 2 hours after consuming the standard lunch)
- Total area under the serum free-fatty acid response curve(For 2 hours after consuming the standard lunch)
研究者
Thomas Wolever
Professor
University of Toronto