A Calcium channel or Angiotensin converting enzyme inhibitor/Angiotensin receptor blocker Regimen to reduce Blood pressure variability in acute ischaemic Stroke (CAARBS): A Feasibility Trial - Antihypertensives to reduce blood pressure variability after stroke

niversity of Leicester0 个研究点目标入组 14 人开始时间: 2017年8月8日最近更新: 2019年12月16日

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•Patients aged over 18 with a first TIA or mild to moderate ischaemic stroke (NIHSS <10) and blood pressure >130/80mmHg, will be recruited within 72 hours of symptom onset. Patients must be willing to comply with the randomly assigned BP-lowering regime and BP measurements, be able to understand written and verbal English and provide informed patient consent, and be willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 75
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 75

•Patients may not enter the trial if any of the following apply:
•Known definite contra-indication to BP-lowering regime or therapeutic agents;
•Swallowing difficulties which would preclude the taking of oral medication;
•Definite indication for beta-blocker, calcium channel blocker, angiotensin converting enzyme inhibitor, or angiotensin receptor blocker therapy;
•Significant pre-stroke dependency (modified Rankin Score >3);
•Co-existing life-threatening condition with life expectancy <3 months;
•Previous participation in this trial or current participation in another investigational drug trial;
•Atrial fibrillation;
•Female participants who are pregnant, lactating or planning pregnancy during the course of the study;
•Participants who intend to donate blood during the study;
•Unable to understand written and verbal English
•Cannot give informed consent.

发起方

niversity of Leicester