Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- neutrophil populations
研究概览
简要总结
In this research study we want to learn more about the character of neutrophils that are present in the blood of children with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in organs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood of children with sepsis so that they can work to develop therapies to prevent these cells from being harmful.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be eligible for enrollment as septic patients if they
- •Are < 18 years old
- •Meet the definition of sepsis described in the study design section above. Patients will be eligible for enrollment as control patients if they
- •Are < 18 years old
- •Are scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure.
排除标准
- •Patients will be ineligible for enrollment in either control or sepsis group if any of the followings is present or anticipated
- •Congenital cardiac disease
- •On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases
结局指标
主要结局
neutrophil populations
时间窗: up to 1 month
compare gene expression in neutrophils between sepsis patients and non-sepsis patients in pediatric population to report unregulated and down regulated genes
次要结局
未报告次要终点
研究者
Koichi Yuki
Cardiac Anesthesiologist
Boston Children's Hospital