NCT00116311Unknown不适用
Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects
Groningen Research Institute for Asthma and COPD1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2005年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.
We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.
Both hypotheses are being tested in sputum and peripheral blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of asthma
- •Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication
- •FEV1 > 70% of predicted
- •Positive skin prick test for house dust mite, cat or grass pollen
- •PC20 methacholine or histamine < 8 mg/ml
- •Asthmatic Subjects -
排除标准
- •Use of systemic steroids in the previous 6 weeks
- •Asthma exacerbations in the previous 6 weeks
- •Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago
- •Healthy Subjects - Inclusion Criteria:
- •No airway complaints
- •FEV1 > 90% of predicted
- •Negative skin prick test
- •PC20 methacholine or histamine > 8 mg/ml
- •Healthy Subjects - Exclusion Criteria:
- •Use of steroids in the previous 6 weeks
- •Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago
研究者
研究点 (1)
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