Salivary Biomarkers of Gingival Inflammation Are Associated With Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Salivary PGLYRP1
研究概览
简要总结
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis.
The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
详细描述
Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals.
Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.
depression regardless of periodontal status.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 53 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who were moderate in severity according to the test result, who had not started drug therapy yet and who had not received antidepressant medication in the last 12 months
排除标准
- •Patients with
- •psychotic disorders
- •autism spectrum disorders
- •other anxiety disorders
- •bipolar disorder
- •mental any organic mental disorder and
- •smokers, substance users
结局指标
主要结局
Salivary PGLYRP1
时间窗: 06-09 2019
Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA.
SalivaryTREM-1
时间窗: 06-09 2019
Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA.
Salivary IL-1β
时间窗: 06-09 2019
Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA.
次要结局
未报告次要终点
研究者
DUYGU ILHAN
Asst. Prof
Medipol University