Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- JAK1/2 pathway activation in gingival tissues
研究概览
简要总结
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
详细描述
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:
Is the JAK1/2 pathway overactivated in periodontitis compared to health?
A secondary outcome will be to describe the histological areas, such as epithelium or lamina propria, where the JAK1/2 pathway will be activated including the different subpopulation of cells.
The protocol include one visit where the gingival biopsies are taken.
Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants will receive diagnosis and treatment of the gingival condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sistemically healthy
排除标准
- •Active Maliganancy
- •History of radiation to the head-neck region
- •Chemotherapy or radiation within the last 5 years
- •History of hepatitis B/C or HIV infection
- •Autoimmune diseases
- •Diagnosis of diabetes
- •Pregnancy or lactation
- •More than 3 hospitalizations over the last 3 years
- •Use of systemic antibiotics over the last 3 months
- •Use of systemic corticosteroids or immunosuppressants over the last 3 months
- •Use of cytokine therapy over the last 3 months
- •Use of large doses of pre/probiotic supplements over the last 3 months
- •Smoke more than 10 cigarettes per day
研究组 & 干预措施
Healthy gingiva
Adults without gingival inflammation diagnosed by a clinical exam
Periodontits
Adults with periodontitis diagnosed by a clinical exam
结局指标
主要结局
JAK1/2 pathway activation in gingival tissues
时间窗: Day 1
The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2. 0 = no phosphorilation 1. = mild phosphorilation 2. = intense phosphorilation
次要结局
未报告次要终点